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Article

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.

Cell reports - 15 Mar 2016

Campbell James, Ryan Colm J, Brough Rachel, Bajrami Ilirjana, Pemberton Helen N, Chong Irene Y, Costa-Cabral Sara, Frankum Jessica, Gulati Aditi, Holme Harriet, Miller Rowan, Postel-Vinay Sophie, Rafiq Rumana, Wei Wenbin, Williamson Chris T, Quigley David A, Tym Joe, Al-Lazikani Bissan, Fenton Timothy, Natrajan Rachael, Strauss Sandra J, Ashworth Alan, Lord Christopher J

Abstract excerpt

One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase genetic dependencies in 117 cancer cell lines from ten cancer types. By integrating the siRNA screen data with molecular profiling data, including exome sequencing data, we show how...

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Identifiers

PMID: 26947069
DOI: 10.1016/j.celrep.2016.02.023
PMCID: PMC4802229

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SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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