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Article

Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer

11 Dec 2017

Abstract excerpt

Abstract Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer the transcriptional activity of 127 TFs through analysis of RNA-seq gene expression data newly generated for 448 cancer cell lines, combined with publicly available datasets to survey a total of 1,056 cancer cell lines...

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PMID: 29229604
DOI: 10.1158/0008-5472.can-17-1679

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