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Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines

8 Apr 2022

Abstract excerpt

Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are key cell-cycle regulators that are frequently dysregulated in human malignancies. CDK4/6 inhibitors are clinically approved for the treatment of hormone receptor–positive, HER2–negative (HR+/HER2−) breast cancer, but improved specificity and reduced toxicity might expand their use to other indications. Through analysis of publicly available genome-wide...

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PMID: 35395071
DOI: 10.1158/0008-5472.can-21-2428

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