Article

Mitochondrial sirtuins <i>sir</i> - <i>2.2</i> and <i>sir</i> - <i>2.3</i> regulate lifespan in C. <i>elegans</i>

2017-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial sirtuins regulate biochemical pathways and are emerging drug targets for metabolic and age-related diseases such as cancer, diabetes, and neurodegeneration. Yet, their functions remain unclear. Here, we uncover a novel physiological role for the C. elegans mitochondrial sirtuins, sir-2.2 and sir-2.3, in lifespan regulation. Using a genetic approach, we demonstrate that sir-2.2...

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Literature Corpus work: 2cc35ab6-ec5f-5cb6-b7ea-08cedef4665e
DOI: 10.1101/181727

Open publication

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