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Sirt1: Def<i>-</i>eating senescence?

7 Nov 2012

Abstract excerpt

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated...

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PMID: 22983125
DOI: 10.4161/cc.22074

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