Article
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010
Berdichevsky Alina, Nedelcu Simona, Boulias Konstantinos, Bishop Nicholas A, Guarente Leonard, Horvitz H Robert
Abstract excerpt
Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about genes that normally act to delay aging and that when mutated cause premature aging (progeria). To seek such genes, we performed a genetic screen for C. elegans mutants that age prematurely. We found...
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