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Article

Genetics and the specificity of the aging process.

Science (New York, N.Y.) - 28 Feb 2003

Hekimi Siegfried, Guarente Leonard

Abstract excerpt

The identification and study of long-lived mutant animals has provided valuable insights into the mechanisms that limit the life-span of organisms. Findings with the gene SIR2 suggest that the rate of aging can be regulated under certain conditions. Indeed, increased expression of SIR2 lengthens life-span by acting on biological processes that promote survival under conditions of scarcity. In addition, studies of...

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PMID: 12610295
DOI: 10.1126/science.1082358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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