Article
Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans.
Genetics - 12 Nov 2025
Chang Sarah M, Franklin Latisha P, Sattar Sampurna, Moro Corinna A, DeGennaro Michael V, LaGanke Nicole G, Hanna-Rose Wendy
Abstract excerpt
Mitochondrial sirtuins regulate metabolism and are emerging drug targets for metabolic and age-related diseases such as cancer, diabetes, and neurodegeneration. Yet, the extent of their functions remains unclear. Here, we uncover a physiological role for the Caenorhabditis elegans mitochondrial sirtuins, sir-2.2 and sir-2.3, in lifespan regulation. Using genetic alleles with deletions that destroy catalytic...
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