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Article

Extended longevity and survivorship during amino-acid starvation in a Drosophila Sir2 mutant heterozygote.

Genome - 1 May 2016

Slade Jennifer D, Staveley Brian E

Abstract excerpt

The regulation of energy homeostasis is pivotal to survive periods of inadequate nutrition. A combination of intricate pathways and proteins are responsible for maximizing longevity during such conditions. The sirtuin deacetylase Sir2 is well conserved from single-celled yeast to mammals, and it controls a number of downstream targets that are active during periods of extreme stress. Overexpression of Sir2 has...

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Identifiers

PMID: 27074822
DOI: 10.1139/gen-2015-0213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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