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Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

Mechanisms of ageing and development - 1 Jan 2006

Wang Yamei, Tissenbaum Heidi A

Abstract excerpt

The conserved SIR2 protein regulates life span in both yeast and worms: in both organisms overexpression of SIR2 can extend life span and in Caenorhabditis elegans this life span extension is dependent on the forkhead transcription factor, DAF-16. Here, we have done extensive genetic analysis with sir-2.1(ok434), a null mutant of C. elegans sir-2.1, the closest homolog to yeast Sir2p and human SIRT1 to further...

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Source

Identifiers

PMID: 16280150
DOI: 10.1016/j.mad.2005.09.005

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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