Article

Conserved epigenetic regulatory logic infers genes governing cell identity

2019-05-12

Abstract excerpt

<h4>SUMMARY</h4> Determining genes orchestrating cell differentiation in development and disease remains a fundamental goal of cell biology. This study establishes a genome-wide metric based on the gene-repressive tri-methylation of histone 3 lysine 27 (H3K27me3) across hundreds of diverse cell types to identify genetic regulators of cell differentiation. We introduce a computational method, TRIAGE, that uses dis...

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Literature Corpus work: b73785f4-68ce-5b2a-94df-893cc5a3c4c3
DOI: 10.1101/635516

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