Article

Pioneer Transcription Factors Differentially Co-opt Bcl11a and Bcl11b to orchestrate Reprogramming

2025-12-22

Abstract excerpt

Pioneer transcription factors (TFs) orchestrate development, reprogramming, and cancer. Yet, the molecular mechanisms by which they cooperate with endogenous TFs and chromatin to trigger cell fate conversions remain largely unknown. Here, we identified antagonistic functions in reprogramming to pluripotency for the two paralogous somatic zinc finger TFs Bcl11a and Bcl11b. We reveal that Bcl11a and Bcl11b are initi...

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Literature Corpus work: 8d4e1721-dd6e-50e0-ae5f-e3bf14ea93ef
DOI: 10.64898/2025.12.19.694617

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