Article

Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming

2019-05-20

Abstract excerpt

<h4>SUMMARY</h4> Direct lineage conversion, whereby a somatic cell assumes a new cellular identity, can be driven by ectopic expression of combinations of lineage-enriched transcription factors. To determine the molecular mechanisms by which expression of Gata4, Mef2c, and Tbx5 (GMT) induces direct reprogramming from a cardiac fibroblast toward an induced cardiomyocyte, we performed a comprehensive transcriptomic...

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Literature Corpus work: af92970f-93fe-5d72-8b16-42b4e3f19aa0
DOI: 10.1101/642900

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