Article

Mouse fertilization triggers a conserved transcription program in one-cell embryos

2020-09-15

Abstract excerpt

Following fertilization, the new embryo reprograms parental genomes to begin transcription (embryonic genome activation, EGA). EGA is indispensable for development, but its dynamics, profile or when it initiates in vertebrates are unknown. We here characterize the onset of transcription in mouse one-cell embryos. Precise embryo staging eliminated noise to reveal a cascading program of de novo transcription initia...

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Literature Corpus work: 0a821e77-1d03-563c-ba0f-daadff80eefc
DOI: 10.1101/2020.09.15.298018

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