Article

sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors

2016-02-04

Abstract excerpt

Accurate identification of copy number alterations is an essential step in understanding the events driving tumor progression. While a variety of algorithms have been developed to use high-throughput sequencing data to profile copy number changes, no tool is able to reliably characterize ploidy and genotype absolute copy number from tumor samples which contain less than 40% tumor cells. To increase our power to re...

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Literature Corpus work: 2c5816a3-c264-5800-aa3b-267fc12d2b4c
DOI: 10.1101/038828

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