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Article

Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy.

Genome research - 1 Feb 2009

Attiyeh Edward F, Diskin Sharon J, Attiyeh Marc A, Mossé Yaël P, Hou Cuiping, Jackson Eric M, Kim Cecilia, Glessner Joseph, Hakonarson Hakon, Biegel Jaclyn A, Maris John M

Abstract excerpt

Microarrays are frequently used to profile genome-wide copy number (CN) aberrations. While generally robust for detecting CN variants in germline DNA, the methods used to derive CN from signal intensity values have been suboptimal when applied to cancer genomes. The complexity of genomic aberrations in cancer makes it more difficult to discriminate between signal and noise, and measuring CN as a discrete variable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19141597
DOI: 10.1101/gr.075671.107
PMCID: PMC2652209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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