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Article

SomatiCA: identifying, characterizing and quantifying somatic copy number aberrations from cancer genome sequencing data.

PloS one - 1 Jan 2013

Chen Mengjie, Gunel Murat, Zhao Hongyu

Abstract excerpt

Whole genome sequencing of matched tumor-normal sample pairs is becoming routine in cancer research. However, analysis of somatic copy-number changes from sequencing data is still challenging because of insufficient sequencing coverage, unknown tumor sample purity and subclonal heterogeneity. Here we describe a computational framework, named SomatiCA, which explicitly accounts for tumor purity and subclonality in...

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PMID: 24265680
DOI: 10.1371/journal.pone.0078143
PMCID: PMC3827077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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