Article

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimer’s Disease with Psychosis

2025-05-07

Abstract excerpt

Approximately 40 percent of Alzheimer’s disease patients develop psychosis (AD+P), yet the molecular and cellular basis of these symptoms remains poorly understood. Here we profiled single-nucleus transcriptomes and epigenomes from 48 postmortem Alzheimer’s brains stratified by psychiatric diagnosis. Across cell types, AD+P was distinguished by transcriptional programs in upper-layer cortical pyramidal neurons con...

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Literature Corpus work: 2b9cbf2e-c725-5cdd-8fd2-026fd60f40c3
DOI: 10.1101/2025.04.30.651435

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