Article

Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cells

2021-02-02

Abstract excerpt

<h4>SUMMARY</h4> The multi-task protein kinase Bub1 has long been considered important for chromosome alignment and spindle assembly checkpoint signaling during mitosis. However, recent studies provide surprising evidence that Bub1 may not be essential in human cells, with the underlying mechanism unknown. Here we show that Bub1 plays a redundant role with the non-essential CENP-U complex in recruiting Polo-like...

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Literature Corpus work: 2b500d5a-06c0-5b15-ab2b-415141f027cb
DOI: 10.1101/2021.02.01.429225

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