Article

The BUBR1 pseudokinase domain promotes efficient kinetochore PP2A-B56 recruitment to regulate spindle checkpoint silencing and chromosome alignment

2019-08-13

Abstract excerpt

<h4>ABSTRACT</h4> The balance of phospho-signalling at outer-kinetochores during mitosis is critical for the accurate attachments between kinetochores and the mitotic spindle and timely exit from mitosis. In humans, a major player in determining this balance is the PP2A-B56 phosphatase which is recruited to the Kinase Attachment Regulatory Domain (KARD) of the Spindle Assembly Checkpoint protein Budding Uninhibit...

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Literature Corpus work: b79a0cce-bc8e-5867-ae60-0b0665f549e9
DOI: 10.1101/733378

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