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Article

Bub1 regulates chromosome segregation in a kinetochore-independent manner.

The Journal of cell biology - 1 Jun 2009

Klebig Christiane, Korinth Dirk, Meraldi Patrick

Abstract excerpt

The kinetochore-bound protein kinase Bub1 performs two crucial functions during mitosis: it is essential for spindle checkpoint signaling and for correct chromosome alignment. Interestingly, Bub1 mutations are found in cancer tissues and cancer cell lines. Using an isogenic RNA interference complementation system in transformed HeLa cells and untransformed RPE1 cells, we investigate the effect of structural Bub1...

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Identifiers

PMID: 19487456
DOI: 10.1083/jcb.200902128
PMCID: PMC2711590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bub1 regulates chromosome segregation in a kinetochore-independent manner.PMID 19487456Read ↗

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BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.Semantic proximity Read ↗

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.Semantic proximity Read ↗

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The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.Semantic proximity Read ↗

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationSemantic proximity Read ↗

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