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Article

Bub1 regulates chromosome segregation in a kinetochore-independent manner.

The Journal of cell biology - 1 Jun 2009

Klebig Christiane, Korinth Dirk, Meraldi Patrick

Abstract excerpt

The kinetochore-bound protein kinase Bub1 performs two crucial functions during mitosis: it is essential for spindle checkpoint signaling and for correct chromosome alignment. Interestingly, Bub1 mutations are found in cancer tissues and cancer cell lines. Using an isogenic RNA interference compl...

Topics

Amino Acid Motifs
Amino Acid Sequence
Chromosome Segregation
Chromosomes, Human
HeLa Cells
Humans
Kinetochores
Mitosis
Molecular Sequence Data
Mutation
Protein Serine-Threonine Kinases
RNA Interference

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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Identifiers

PMID: 19487456
DOI: 10.1083/jcb.200902128
PMCID: PMC2711590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19487456-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Bub1 regulates chromosome segregation in a kinetochore-independent manner.PMID 19487456Read ↗

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Semantic proximity Read ↗

Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cellsSemantic proximity Read ↗

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.Semantic proximity Read ↗

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.Semantic proximity Read ↗

Distinct chromosome segregation roles for spindle checkpoint proteins.Semantic proximity Read ↗

The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.Semantic proximity Read ↗

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationSemantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

BubR1 kinase: protection against aneuploidy and premature aging.Semantic proximity Read ↗

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