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Article

BubR1 kinase: protection against aneuploidy and premature aging.

Trends in molecular medicine - 1 Jun 2015

Kapanidou Maria, Lee Semin, Bolanos-Garcia Victor M

Abstract excerpt

The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. We discuss the roles of BubR1 in the SAC and the implications of BubR1-mediated...

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Identifiers

PMID: 25964054
DOI: 10.1016/j.molmed.2015.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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