BubR1 kinase: protection against aneuploidy and premature aging.

doi:10.1016/j.molmed.2015.04.003

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Article

BubR1 kinase: protection against aneuploidy and premature aging.

Trends in molecular medicine - 1 Jun 2015

Kapanidou Maria, Lee Semin, Bolanos-Garcia Victor M

Abstract excerpt

The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are prope...

Topics

Aging, Premature
Aneuploidy
Animals
Genomic Instability
Humans
M Phase Cell Cycle Checkpoints
Models, Molecular
Molecular Targeted Therapy
Mutation
Neoplasms
Protein Serine-Threonine Kinases

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