Article

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cells

2022-07-21

Abstract excerpt

<h4>Summary</h4> Chromosome alignment to the spindle equator is a hallmark of mitosis that is thought to promote chromosome segregation fidelity in metazoans. Yet, chromosome alignment is only indirectly supervised by the spindle assembly checkpoint (SAC) as a byproduct of chromosome bi-orientation, and the consequences of defective chromosome alignment remain unclear. Here we investigated how human cells respond...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ba627f1-e1a1-5a0b-8a05-fe45be2248fb
DOI: 10.1101/2022.07.20.500828

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cellsDOI 10.1101/2022.07.20.500828Read

Mitotic chromosome alignment is required for proper nuclear envelope reassemblySemantic proximity Read

An anaphase surveillance mechanism prevents micronuclei formation from mitotic errorsSemantic proximity Read

Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progressionSemantic proximity Read

Measuring and modeling the dynamics of mitotic error correctionSemantic proximity Read

Non-Random Mis-Segregation of Human ChromosomesSemantic proximity Read

Cell confinement initiates a delayed but heritable loss of chromosomesSemantic proximity Read

Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity Read

High-resolution imaging reveals how the spindle midzone impacts chromosome movementSemantic proximity Read

DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly CheckpointSemantic proximity Read

Double-checking chromosome segregationSemantic proximity Read

Cell enlargement causes mitotic errors and aneuploidy in cells that evade senescence after CDK4/6 inhibitionSemantic proximity Read

Chromatin Bridges, not Micronuclei, Activate cGAS after Drug-induced Mitotic Errors in Human CellsSemantic proximity Read