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Article

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.

The Journal of cell biology - 23 Jul 2012

Guo Yige, Kim Christine, Ahmad Sana, Zhang Jiayin, Mao Yinghui

Abstract excerpt

How the state of spindle microtubule capture at the kinetochore is translated into mitotic checkpoint signaling remains largely unknown. In this paper, we demonstrate that the kinetochore-associated mitotic kinase BubR1 phosphorylates itself in human cells and that this autophosphorylation is dependent on its binding partner, the kinetochore motor CENP-E. This CENP-E-dependent BubR1 autophosphorylation at...

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Identifiers

PMID: 22801780
DOI: 10.1083/jcb.201202152
PMCID: PMC3410423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.PMID 22801780Read ↗

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