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Article

BUB1 and BUBR1: multifaceted kinases of the cell cycle.

Trends in biochemical sciences - 1 Mar 2011

Bolanos-Garcia Victor M, Blundell Tom L

Abstract excerpt

The multidomain protein kinases BUB1 and BUBR1 (Mad3 in yeast, worms and plants) are central components of the mitotic checkpoint for spindle assembly (SAC). This evolutionarily conserved and essential self-monitoring system of the eukaryotic cell cycle ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle....

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Identifiers

PMID: 20888775
DOI: 10.1016/j.tibs.2010.08.004
PMCID: PMC3061984

Genes

BUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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