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Article

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.

Nature communications - 14 Apr 2020

Ehlén Åsa, Martin Charlotte, Miron Simona, Julien Manon, Theillet François-Xavier, Ropars Virginie, Sessa Gaetana, Beaurepere Romane, Boucherit Virginie, Duchambon Patricia, El Marjou Ahmed, Zinn-Justin Sophie, Carreira Aura

Abstract excerpt

The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-like kinase 1 (PLK1). Here we describe how this phosphorylation contributes to the control of mitosis. We identify a conserved phosphorylation site at T207 of BRCA2 that constitutes a bona fide docking site for PLK1 and is phosphorylated in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32286328
DOI: 10.1038/s41467-020-15689-9
PMCID: PMC7156385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.PMID 32286328Read ↗

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Semantic proximity Read ↗

CIP2A coordinates phosphosignaling, mitosis, and the DNA damage responseSemantic proximity Read ↗

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.Semantic proximity Read ↗

M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.Semantic proximity Read ↗

BRCA1 is regulated by Chk2 in response to spindle damage.Semantic proximity Read ↗

Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cellsSemantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functionsSemantic proximity Read ↗

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks.Semantic proximity Read ↗

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombinationSemantic proximity Read ↗

Polo-like kinase-activating kinasesSemantic proximity Read ↗

The BUBR1 pseudokinase domain promotes efficient kinetochore PP2A-B56 recruitment to regulate spindle checkpoint silencing and chromosome alignmentSemantic proximity Read ↗

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