Article

Signaling protein abundance modulates the strength of the Spindle Assembly Checkpoint

2022-05-10

Abstract excerpt

<h4>Summary</h4> During mitosis, unattached kinetochores in a dividing cell signal to the Spindle Assembly Checkpoint to delay anaphase onset and prevent chromosome missegregation 1–4 . The signaling activity of these kinetochores and the likelihood of chromosome missegregation both depend on the amount of SAC signaling proteins that each kinetochore recruits 5–8 . Therefore, factors that control SAC protein re...

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Literature Corpus work: 70c12e19-5a7c-5c01-8512-7350baf8546c
DOI: 10.1101/2022.05.10.491369

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