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An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity

2023-08-07

Abstract excerpt

<h4>Summary</h4> Cancer cells are often aneuploid and frequently display elevated rates of chromosome mis-segregation in a phenomenon called chromosomal instability (CIN). CIN is commonly caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduces the efficiency of correction of erroneous K-MT attachments. We recently showed that UMK57, a chemical agonist of MCAK (alias KIF2C) improves chromosom...

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Literature Corpus work
236fda0f-5992-5738-8c6d-7e5206786fd8
DOI
10.1101/2023.08.06.552174
Open publication

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An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelityDOI 10.1101/2023.08.06.552174
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