Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

doi:10.1158/0008-5472.CAN-07-6330

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Article

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

Cancer research - 1 Jan 2009

Schliekelman Mark, Cowley Dale O, O'Quinn Ryan, Oliver Trudy G, Lu Lucy, Salmon E D, Van Dyke Terry

Abstract excerpt

Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast. Bub1 binding at kinetochores has been reported to be required for SAC function and localization of other SAC components. A proper SAC is believed to be essential for murine embryonic development, as all previously described null mutations in SAC components in mice cause embryonic...

Topics

Alleles
Aneuploidy
Animals
Cell Cycle Proteins
Cell Transformation, Neoplastic
Chromosome Segregation
Female
Fibroblasts
Kinetochores
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mutation

Nocodazole

Paclitaxel

Protein Serine-Threonine Kinases

RNA, Messenger

Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 19117986
DOI: 10.1158/0008-5472.CAN-07-6330
PMCID: PMC4770788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19117986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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