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Article

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

Cancer research - 1 Jan 2009

Schliekelman Mark, Cowley Dale O, O'Quinn Ryan, Oliver Trudy G, Lu Lucy, Salmon E D, Van Dyke Terry

Abstract excerpt

Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast. Bub1 binding at kinetochores has been reported to be required for SAC function and localization of other SAC components. A proper SAC is believed to be essential for murine embryonic development, as all previously described null mutations in SAC components in mice cause embryonic...

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Identifiers

PMID: 19117986
DOI: 10.1158/0008-5472.CAN-07-6330
PMCID: PMC4770788

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Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.PMID 19117986Read ↗

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