Article

Nucleosome-directed replication origin licensing independent of a consensus DNA sequence

2021-08-18

Abstract excerpt

<h4>ABSTRACT</h4> The numerous enzymes and cofactors involved in eukaryotic DNA replication are conserved from yeast to human, and the budding yeast Saccharomyces cerevisiae (S.c.) has been a useful model organism for these studies. However, there is a gap in our knowledge of why replication origins in higher eukaryotes do not use a consensus DNA sequence as found in S.c.. Using in vitro reconstitution and singl...

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Literature Corpus work: 91605ad4-e79f-5f4e-bee7-afe2eb37d907
DOI: 10.1101/2021.08.17.456647

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