Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

Abstract excerpt

Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. Here we combined spatial transcriptomics and scRNA-Seq to define the transcriptome of tumor-proximal and tumor-distal cancer-associated f...

Topics

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• Cancer Cells and Metastasis
• Cancer Genomics and Diagnostics
• Cancer, Hypoxia, and Metabolism
• Pancreatic and Hepatic Oncology Research
• Pancreatic function and diabetes
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

5de91edd-2111-5418-a130-98a4e8bee373

DOI

10.1101/2023.01.20.524883