Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer

1 Nov 2024

Abstract excerpt

ABSTRACT: Cancer progression and response to therapy are inextricably reliant on the coevolution of a supportive tissue microenvironment. This is particularly evident in pancreatic ductal adenocarcinoma, a tumor type characterized by expansive and heterogeneous stroma. Herein, we employed single-cell RNA sequencing and spatial transcriptomics of normal, inflamed, and malignant pancreatic tissues to contextualize...

Source

Identifiers

PMID: 39485038
DOI: 10.1158/2767-9764.crc-23-0489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic CancerPMID 39485038Read ↗

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsiesSemantic proximity Read ↗

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsiesSemantic proximity Read ↗

High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survivalSemantic proximity Read ↗

Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtypeSemantic proximity Read ↗

Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer BiopsiesSemantic proximity Read ↗

Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinomaSemantic proximity Read ↗

Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Spatially confined sub-tumor microenvironments in pancreatic cancer.Semantic proximity Read ↗

Integrating multi-modal transcriptomics identifies cellular subtypes with distinct roles in PDAC progressionSemantic proximity Read ↗

Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosisSemantic proximity Read ↗

Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysisSemantic proximity Read ↗

Inflammatory Signaling in Pancreatic Cancer Transfers Between a Single-cell RNA Sequencing Atlas and Co-CultureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.