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Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment

3 Feb 2020

Abstract excerpt

The poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) impels an improved understanding of disease biology to facilitate the development of better therapies. PDAC typically features a remarkably dense stromal reaction, featuring and established by a prominent population of cancer-associated fibroblasts (CAF). Genetically engineered mouse models and increasingly sophisticated cell culture...

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PMID: 32014869
DOI: 10.1158/2159-8290.cd-19-1353

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