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Article

Hypoxia-Induced Fibroblast IL-6 Promotes Immunosuppressive Macrophage Phenotypes in Pancreatic Cancer.

Cells - 13 Apr 2026

Hannifin Sean, Mello Ashley M, Ngodup Tenzin, Kim Nam Hoon, Pasca di Magliano Marina, Lee Kyoung Eun

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterized by a dense fibroinflammatory stroma and profound hypoxia. Using pancreatic stellate cell-tumor organoid coculture models and single-cell RNA sequencing analyses, we uncover that hypoxia-driven fibroblast reprogramming promotes immunosuppressive macrophage phenotypes in PDAC. Mechanistically, hypoxia acts through tumor-fibroblast...

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Identifiers

PMID: 42041553
DOI: 10.3390/cells15080683
PMCID: PMC13114822

Genes

ARG1
IL6
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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