Article

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming

2021-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic KRAS is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. While the tumor cell-intrinsic effects of oncogenic Kras expression have been widely studied, its role in regulating the extensive pancreatic tumor microenvironment is less understood. Using a genetically engineered mouse model of inducible and r...

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Literature Corpus work: e0c17f50-03b8-5af3-a5bd-9e789cf34edc
DOI: 10.1101/2021.08.26.457660

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