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Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

2021-02-19

Abstract excerpt

<h4>Summary</h4> Pancreatic ductal adenocarcinoma (PDAC) remains resistant to most treatments and demonstrates a complex pathobiology. Here, we deconvolute regional heterogeneity in the human PDAC tumor microenvironment (TME), a long-standing obstacle, to define precise stromal contributions to PDAC progression. Large scale integration of histology-guided multiOMICs with clinical data sets and functional in vitr...

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Identifiers and source

Literature Corpus work
1b8099df-6c05-5034-9390-26bc71ae475f
DOI
10.1101/2021.02.18.431890
Open publication

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Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiologyDOI 10.1101/2021.02.18.431890
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