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Article

Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtype

26 Aug 2023

Abstract excerpt

Bulk analyses of pancreatic ductal adenocarcinoma (PDAC) samples are complicated by the tumor microenvironment (TME), i.e. signals from fibroblasts, endocrine, exocrine, and immune cells. Despite this, we and others have established tumor and stroma subtypes with prognostic significance. However, understanding of underlying signals driving distinct immune and stromal landscapes is still incomplete. Here we...

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PMID: 37633924
DOI: 10.1038/s41467-023-40895-6

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