Article

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

2021-12-21

Abstract excerpt

<h4>Summary</h4> Germinal centers (GCs) are the engines of antibody evolution. Using HIV Env protein immunogen priming in rhesus monkeys (RM) followed by a long period without further immunization, we demonstrate GC B cells (B GC ) lasted at least 6 months (29 weeks), all the while maintaining rapid proliferation. A 186-fold B GC cell increase was present by week 10 compared to a conventional immunization. Sing...

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Literature Corpus work: b4c94a4a-d26c-5b3b-ae34-def1fbf8c32d
DOI: 10.1101/2021.12.20.473537

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