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Article

Diverse priming outcomes under conditions of very rare precursor B cells

1 Apr 2025

Abstract excerpt

Rare naive B cells have special pathogen-recognition features that enable outsized contributions to protective immunity but infrequently participate in immune responses. We investigatee how germline-targeting vaccine delivery and adjuvant selection affect priming of exceptionally rare BG18-like HIV broadly neutralizing antibody-precursor B cells (<1-in-50 million) in non-human primates. Only escalating dose (ED)...

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PMID: 40168992
DOI: 10.1016/j.immuni.2025.03.003

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