Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2017

Chung Wei-Jen, Daemen Anneleen, Cheng Jason H, Long Jason E, Cooper Jonathan E, Wang Bu-Er, Tran Christopher, Singh Mallika, Gnad Florian, Modrusan Zora, Foreman Oded, Junttila Melissa R

Abstract excerpt

KRAS mutant tumors are largely recalcitrant to targeted therapies. Genetically engineered mouse models (GEMMs) of Kras mutant cancer recapitulate critical aspects of this disease and are widely used for preclinical validation of targets and therapies. Through comprehensive profiling of exomes and matched transcriptomes of >200 KrasG12D-initiated GEMM tumors from one lung and two pancreatic cancer models, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Genomics

Share to MAP Kinase Signaling System

Share to Neoplasms

Share to Selection, Genetic

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 29203670
DOI: 10.1073/pnas.1708391114
PMCID: PMC5754767

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous.PMID 29203670Read ↗

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.Semantic proximity Read ↗

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.Semantic proximity Read ↗

The mutational landscape of <i>EGFR-</i> , <i>MYC-</i> , and <i>Kras-</i> driven genetically-engineered mouse models of lung adenocarcinomaSemantic proximity Read ↗

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung CancerSemantic proximity Read ↗

RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Semantic proximity Read ↗

Genetic determinants of <i>EGFR</i> -Driven Lung Cancer Growth and Therapeutic Response <i>In Vivo</i>Semantic proximity Read ↗

Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial OutcomesSemantic proximity Read ↗

Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models.Semantic proximity Read ↗

An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.Semantic proximity Read ↗

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.Semantic proximity Read ↗

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models.Semantic proximity Read ↗

A disease model resource reveals core principles of tissue-specific cancer evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.