Article
The genetics and biology of KRAS in lung cancer.
Chinese journal of cancer - 1 Feb 2013
Westcott Peter M K, To Minh D
Abstract excerpt
Mutational activation of KRAS is a common oncogenic event in lung cancer and other epithelial cancer types. Efforts to develop therapies that counteract the oncogenic effects of mutant KRAS have been largely unsuccessful, and cancers driven by mutant KRAS remain among the most refractory to available treatments. Studies undertaken over the past decades have produced a wealth of information regarding the clinical...
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