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A multiplexed in vivo approach to identify driver genes in small cell lung cancer

2022-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Small cell lung cancer (SCLC) is a highly lethal form of lung cancer. The high mutation burden in SCLC cells makes it challenging to predict key drivers of SCLC from genome sequencing data, thereby hindering the identification of possible therapeutic targets. Here we develop a quantitative multiplexed approach based on lentiviral barcoding with somatic CRISPR/Cas9-mediated genome editing to func...

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Literature Corpus work
8f067606-93c2-5215-95fa-31a29d1c67bf
DOI
10.1101/2022.03.28.485708
Open publication

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A multiplexed in vivo approach to identify driver genes in small cell lung cancerDOI 10.1101/2022.03.28.485708
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