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Article

A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer

19 Feb 2021

Abstract excerpt

Abstract Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis is a multistep process, but the importance and specific roles of many of these genes during tumor initiation, growth, and progression remain unknown. Here we use a multiplexed mouse model of oncogenic KRAS–driven lung cancer to quantify the impact of 48 known and putative tumor suppressor genes on diverse...

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PMID: 33608386
DOI: 10.1158/2159-8290.cd-20-1325

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