Article
Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth.
Nature cell biology - 1 Jan 2023
Tang Rui, Shuldiner Emily G, Kelly Marcus, Murray Christopher W, Hebert Jess D, Andrejka Laura, Tsai Min K, Hughes Nicholas W, Parker Mitchell I, Cai Hongchen, Li Yao-Cheng, Wahl Geoffrey M, Dunbrack Roland L, Jackson Peter K, Petrov Dmitri A, Winslow Monte M
Abstract excerpt
Oncogenic KRAS mutations occur in approximately 30% of lung adenocarcinoma. Despite several decades of effort, oncogenic KRAS-driven lung cancer remains difficult to treat, and our understanding of the regulators of RAS signalling is incomplete. Here to uncover the impact of diverse KRAS-interacting proteins on lung cancer growth, we combined multiplexed somatic CRISPR/Cas9-based genome editing in genetically...
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