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Article

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Nature - 18 Dec 2014

Sánchez-Rivera Francisco J, Papagiannakopoulos Thales, Romero Rodrigo, Tammela Tuomas, Bauer Matthew R, Bhutkar Arjun, Joshi Nikhil S, Subbaraj Lakshmipriya, Bronson Roderick T, Xue Wen, Jacks Tyler

Abstract excerpt

Cancer is a multistep process that involves mutations and other alterations in oncogenes and tumour suppressor genes. Genome sequencing studies have identified a large collection of genetic alterations that occur in human cancers. However, the determination of which mutations are causally related to tumorigenesis remains a major challenge. Here we describe a novel CRISPR/Cas9-based approach for rapid functional...

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Identifiers

PMID: 25337879
DOI: 10.1038/nature13906
PMCID: PMC4292871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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