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Progranulin deficiency induces lipid droplet accumulation in microglia via a STAT3-GPAT3 axis

2026-01-20

Abstract excerpt

Heterozygous mutations in the progranulin (PGRN) encoding gene GRN cause frontotemporal dementia (FTD), whereas homozygous GRN mutations lead to neuronal ceroid lipofuscinosis (NCL). However, the mechanisms underlying neurodegeneration due to PGRN deficiency remain unclear. In the aged brains or under neurodegenerative conditions, the accumulation of lipid droplets (LDs) in microglia contributes to cellular dysf...

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Identifiers and source

Literature Corpus work
084784a7-ca82-573a-a1b4-80fb8905b229
DOI
10.64898/2026.01.17.700052
Open publication

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Progranulin deficiency induces lipid droplet accumulation in microglia via a STAT3-GPAT3 axisDOI 10.64898/2026.01.17.700052
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