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Article

Nrf2: bane or blessing in cancer?

Journal of cancer research and clinical oncology - 1 Aug 2014

Xiang MingJun, Namani Akhileshwar, Wu ShiJun, Wang XiaoLi

Abstract excerpt

BACKGROUND: The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor-E2-related factor 2 (Nrf2)-antioxidant response element pathway serves a major function in endogenous cytoprotection in normal cells. Nrf2 is a transcription factor that mainly regulates the expression of a wide array of genes that produce the antioxidants and other proteins responsible for the detoxification of xenobiotics and reactive...

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Identifiers

PMID: 24599821
DOI: 10.1007/s00432-014-1627-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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