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Article

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

1 Jan 2012

Abstract excerpt

The Keap1-Nrf2 [Kelch-like ECH-associated protein 1-nuclear factor (erythroid-derived 2)-like 2] pathway plays a central role in the protection of cells against oxidative and xenobiotic stresses. Nrf2 is a potent transcription activator that recognizes a unique DNA sequence known as the antioxidant response element (ARE). Under normal conditions, Nrf2 binds to Keap1 in the cytoplasm, resulting in proteasomal...

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Identifiers

PMID: 23272301
DOI: 10.3389/fonc.2012.00200

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