Article
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
Molecular and cellular biology - 1 Jan 2006
Kobayashi Akira, Kang Moon-Il, Watai Yoriko, Tong Kit I, Shibata Takahiro, Uchida Koji, Yamamoto Masayuki
Abstract excerpt
The Keap1-Nrf2 system is the major regulatory pathway of cytoprotective gene expression against oxidative and/or electrophilic stresses. Keap1 acts as a stress sensor protein in this system. While Keap1 constitutively suppresses Nrf2 activity under unstressed conditions, oxidants or electrophiles provoke the repression of Keap1 activity, inducing the Nrf2 activation. However, the precise molecular mechanisms...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Substitution
- Animals
- Cell Nucleus
- Cells, Cultured
- Cysteine
- Cytoskeletal Proteins
- Kelch-Like ECH-Associated Protein 1
- Mice
- Mutation
- Nerve Growth Factors
- Oxidative Stress
- Proteasome Endopeptidase Complex