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Article

A systematic analysis of the human Nrf2 network

2016-01-01

Abstract excerpt

Nrf2 is the main transcriptional controller of cellular oxidative stress responses. This is achieved by driving the transcription of a battery of cytoprotective genes that possess a characteristic Antioxidant Response Element (ARE) sequence in their upstream promoter regions. As such, the Nrf2 signalling pathway plays a vital role in health, aging and disease. Defects in Nrf2 activity can lead to impaired mitochon...

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Literature Corpus work
abc30244-394e-5b93-94b2-748745abca4c
DOI
10.17638/03001771
Open publication

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